BDBM50383274 CHEMBL1229592::US10167264, WZ4002::US9670213, WZ4002

SMILES COc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCN(C)CC1

InChI Key InChIKey=ITTRLTNMFYIYPA-UHFFFAOYSA-N

Data  53 IC50  8 Kd  6 EC50

PDB links: 3 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 67 hits for monomerid = 50383274   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of wild type EGFR (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET based Z'-lyte assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of EGFR (unknown origin) after 1.5 hr by FRET-based Z-lyte assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  16nMAssay Description:Inhibition of wild type N-terminal His6-tagged human EGFR kinase domain (702 to 1016 residues) expressed in Sf9 cells pre-incubated for 30 mins befor...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  0.420nMAssay Description:Inhibition of GST-tagged human recombinant EGFR catalytic domain (668 to 1210 amino acids) L858R mutant expressed in Sf9 cells pre-incubated for 30 m...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  0.190nMAssay Description:Inhibition of GST-tagged human recombinant EGFR catalytic domain (668 to 1210 amino acids) T790M/L858R mutant expressed in Sf9 cells pre-incubated fo...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataKd:  150nMAssay Description:Binding affinity to JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  10nMAssay Description:Inhibition of wild type EGFR (unknown origin) expressed in Sf9 cells pre-incubated for 30 mins before substrate and ATP addition by homogeneous time-...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  31nMAssay Description:Inhibition of wild-type EGFR (unknown origin) expressed in baculovirus expression system after 1 hr by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  9.70nMAssay Description:Inhibition of EGFR T790M/L858R mutant (unknown origin) expressed in baculovirus expression system after 1 hr by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  9.58nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [L858R](Homo sapiens (Human))
East China University of Science and Technology

US Patent
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  2.60nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
East China University of Science and Technology

US Patent
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  1.02nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  6.18nMAssay Description:Inhibition of EGFR after 1.5 hr by FRET assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataKd:  46nMAssay Description:Binding affinity to EGFRMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataKd:  46nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-745,751-1210](Homo sapiens (Human))
Jiangsu Medolution

US Patent
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataKd:  12nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  11nMAssay Description:Inhibition of binding of [3H][D-Ala2,D-Leu5]enkephalin to Opioid receptor delta 1 in the rat brain homogenateMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of wild-type EGFR (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50: <1nMAssay Description:Inhibition of wild type N-terminal GST-fused human EGFR cytoplasmic domain expressed in baculovirus expression system preincubated for 30 mins follow...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  1.82E+4nMAssay Description:Inhibition of EGFR in human NCI-H460 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Mus musculus)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  9.69E+3nMAssay Description:Inhibition of ABL in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Mus musculus)
St. John'S University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  1.63E+4nMAssay Description:Inhibition of ABL T315I mutant in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  8.60E+3nMAssay Description:Inhibition of EGFR E746_A750 deletion/T790M mutant in human growth-resistant PC9 cells assessed as reduction in cell viability after 72 hrs by MTT as...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  110nMAssay Description:Inhibition of EGFR E746_A750 deletion mutant in human PC9 cells assessed as reduction in cell viability after 72 hrs by MTT assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  46nMAssay Description:Inhibition of EGFR L858R/T790M mutant phosphorylation in human NCI-H1975 cells after 1 hr by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  18nMAssay Description:Inhibition of recombinant human GST-tagged wild-type EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system using ...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  710nMAssay Description:Inhibition of wild-type EGFR phosphorylation in human A431 cells preincubated for 1 hr followed by EGF stimulation measured after 45 mins by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant human GST-tagged EGFR L858R/T790M mutant cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression syst...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  10nMAssay Description:Inhibition of wild type N-terminal GST-fused human EGFR cytoplasmic domain expressed in baculovirus expression system preincubated for 30 mins follow...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50: <1nMAssay Description:Inhibition of human recombinant GST-tagged EGFR L858R mutant expressed in baculovirus expression system preincubated for 30 mins followed by ATP and ...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  79nMAssay Description:Inhibition of wild type recombinant human EGFR preincubated for 10 mins followed by FAM-labeled peptide/ATP addition measured after 1 hr by mobility ...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  31nMAssay Description:Inhibition of human recombinant EGFR T790M/L858R double mutant preincubated for 10 mins followed by FAM-labeled peptide/ATP addition measured after 1...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  1.18E+3nMAssay Description:Inhibition of wild type EGFR phosphorylation in human LoVo cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  44nMAssay Description:Inhibition of EGFR exon 19 deletion activating mutant phosphorylation in human PC9 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  23nMAssay Description:Inhibition of EGFR L858R/T970M double mutant phosphorylation in human NCI-H1975 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  0.660nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of wild type EGFR (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of wild type EGFR (unknown origin) after 1.5 hrs by FRET-based Z'Lyte assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of EGFR L858R/T90M double mutant (unknown origin) after 1.5 hrs by FRET-based Z'Lyte assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) after 1.5 hrs by FRET-based Z'Lyte assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  120nMAssay Description:Inhibition of wild type GST-tagged human EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system using Poly G:T (4:...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataEC50:  989nMAssay Description:Inhibition of wild type EGFR (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTS assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  5nMAssay Description:Inhibition of GST-tagged human EGFR T790M mutant cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system using Poly G:T ...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  990nMAssay Description:Inhibition of GST-tagged human ALK cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus expression system using Poly G:T (4:1) as subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataEC50:  31nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  4nMAssay Description:Inhibition of GST-tagged human EGFR T790M/L858R double mutant cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system us...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataEC50:  26nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTS assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataEC50:  68nMAssay Description:Inhibition of EGFR exon19 deletion mutant (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MT...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataEC50:  27nMAssay Description:Inhibition of EGFR T790M exon19 deletion double mutant (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after...More data for this Ligand-Target Pair